| Expression pattern: |
DN |
| Associated gene: |
BCL2L10 |
| Associated microRNA: |
miR-1229 |
| Biological function: |
inhibits CRC cell proliferation and migration (tumor suppressor role) |
| Molecular mechanism: |
ceRNA mechanism: circTADA2A sponges miR-1229 to regulate BCL2L10 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; Microarray |
| Clinical significance: |
circTADA2A might represent a novel potential target for the treatment of CRC |
| Description: |
circTADA2A is down-regulated in colorectal cancer and acts as a tumor suppressor by inhibiting proliferation and migration. It functions as a ceRNA that sponges miR-1229 to relieve miR-1229-mediated suppression of BCL2L10. |
| Confidence score: |
0.8111 |