| Expression pattern: |
UP |
| Associated gene: |
TRIM66 / tripartite motif-containing protein 66 / Ago2 |
| Associated microRNA: |
miR-150-5p |
| Biological function: |
CircSATB2 facilitates NSCLC cell proliferation, migration, invasion, motility, malignant behaviors, and xenograft tumor growth, while suppressing apoptosis. |
| Molecular mechanism: |
CircSATB2 acts as a ceRNA/molecular sponge for miR-150-5p to indirectly upregulate TRIM66 expression, thereby promoting malignant behaviors in NSCLC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Western Blot; IHC (Immunohistochemistry); Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
CircSATB2 may have value as a prognostic biomarker and circRNA-targeted therapeutic target for NSCLC. |
| Description: |
CircSATB2/hsa_circ_0008928 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell growth, migration, invasion, EMT-related marker changes, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circSATB2 functions as a ceRNA for miR-150-5p, relieving miR-150-5p-mediated repression of TRIM66. |
| Confidence score: |
0.8175 |