| Expression pattern: |
UP |
| Associated gene: |
VMA21 |
| Associated microRNA: |
miR-525-5p |
| Biological function: |
promotes LUAD cell growth, proliferation, migration, invasion and xenograft tumor growth |
| Molecular mechanism: |
ceRNA sponge mechanism: circ_0001361 binds miR-525-5p to increase VMA21 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
circ_0001361 as a potential prognosis biomarker and therapeutic target for clinical treatment of LUAD |
| Description: |
circ_0001361 is up-regulated in LUAD tissues and cell lines and mainly localizes to the cytoplasm. It promotes LUAD proliferation and metastatic behaviors by sponging miR-525-5p, thereby increasing VMA21 expression, and its silencing suppresses xenograft tumor growth. |
| Confidence score: |
0.7523 |