| Expression pattern: |
DN |
| Associated gene: |
FBXW7 |
| Associated microRNA: |
miR-544a |
| Biological function: |
Inhibits NSCLC cell proliferation, migration, and invasion; increases apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Acts as a competing endogenous RNA by sponging miR-544a, thereby modulating FBXW7 protein level. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
Low hsa_circ_11780 expression is associated with large tumor size, distant metastasis, advanced TNM stage, and inferior overall survival in NSCLC. |
| Description: |
hsa_circ_11780 is down-regulated in NSCLC and acts as a tumor suppressor by inhibiting proliferation, migration/invasion and promoting apoptosis. Mechanistically, it sponges miR-544a and modulates the miR-544a-FBXW7 protein axis, and low expression is associated with metastasis and worse overall survival. |
| Confidence score: |
0.7976 |