| Expression pattern: |
UP |
| Associated gene: |
MMP-2, MMP-9 |
| Associated microRNA: |
miR-199-3p |
| Biological function: |
promotes proliferation and invasion |
| Molecular mechanism: |
circFLNA negatively regulates miR-199-3p and acts as a ceRNA (miRNA sponge) |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay; Survival Analysis |
| Clinical significance: |
high circFLNA expression levels were associated with a worse prognosis in GBM |
| Description: |
circFLNA (hsa_circ_0092012) is up-regulated in glioblastoma tissues and GBM cell lines and promotes GBM cell proliferation and invasion. Mechanistically, circFLNA interacts with and suppresses miR-199-3p, consistent with a ceRNA/miRNA-sponge model, and high circFLNA expression is associated with worse overall survival. |
| Confidence score: |
0.7916 |