| Expression pattern: |
DN |
| Associated gene: |
carcinoembryogenic antigen (CEA) |
| Associated microRNA: |
- |
| Biological function: |
May play an important role in gastric cancer and serves as a potential diagnostic biomarker in plasma. |
| Molecular mechanism: |
Predicted circRNA-miRNA interactions (potential miRNA sponge/ceRNA), not experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; divergent primers PCR; Bioinformatics Analysis; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Down-regulated in GC tissues and plasma; plasma level shows diagnostic value (ROC AUC 0.683) and combined with CEA increases AUC to 0.775; tissue levels correlate with tumor differentiation and plasma levels correlate with TNM stage. |
| Description: |
This study reports that hsa_circ_0000745 (host gene SPECC1) is down-regulated in gastric cancer tissues and in plasma from GC patients. Its plasma level shows diagnostic value by ROC analysis and improves when combined with CEA; predicted miRNA-binding suggests a potential miRNA-sponge/ceRNA role but without functional experimental validation. |
| Confidence score: |
0.5963 |