| Expression pattern: |
DN |
| Associated gene: |
Wnt/beta-catenin signaling, DVL2, GSK-3beta, beta-catenin, CyclinD1 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis in gastric cancer cells; involved in As4S4-modulated biological behavior alterations |
| Molecular mechanism: |
circRNA_ASAP2 activates Wnt/beta-catenin signaling (increasing DVL2, GSK-3beta, beta-catenin and CyclinD1), and As4S4 suppresses gastric cancer progression by downregulating circRNA_ASAP2 and inactivating Wnt/beta-catenin; Wnt agonist SKL2001 reverses effects of circRNA_ASAP2 knockdown |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot |
| Clinical significance: |
- |
| Description: |
circRNA_ASAP2 is downregulated in gastric cancer cells vs. normal gastric epithelial cells. Functionally, circRNA_ASAP2 promotes GC cell proliferation, migration and invasion and inhibits apoptosis, at least partly by activating Wnt/beta-catenin signaling; As4S4 suppresses GC progression by downregulating circRNA_ASAP2 and inhibiting Wnt/beta-catenin activity. |
| Confidence score: |
0.47 |