circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA_089763
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002039
MONDO name: cognitive disorder
Disease details: post-operative cognitive dysfunction
Disease DO ID:
 1561
Disease MeSH ID:
 D019965
Disease NCIt ID:
 C92196
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: IGFBP5, STC-1, YWHAG
Associated microRNA: hsa-miR-670-3p, hsa-miR-6856-3p, hsa-miR-6769b-3p, hsa-miR-7111-3p, hsa-miR-6803-3p, hsa-miR-614, hsa-miR-6784-3p, hsa-miR-454-5p, hsa-miR-6798-3p, hsa-miR-3684
Biological function: May indirectly regulate cognitive function in POCD (proposed).
Molecular mechanism: Putative ceRNA/miRNA sponge mechanism: circRNA-089763 sequesters multiple miRNAs to indirectly regulate target genes (e.g., IGFBP5, STC-1, YWHAG).
Biological pathway or process:

Hippo/YAP (other); FoxO signaling (other); other pathway/process (other); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circRNA-089763 may be a novel biomarker for POCD after CABG.
Description:

This study identified circRNA_089763 as significantly up-regulated in plasma exosomes of POCD patients after CABG (validated by RT-qPCR). Bioinformatic prediction suggests circRNA_089763 may act as a ceRNA to sponge multiple miRNAs and indirectly affect targets such as IGFBP5, STC-1 and YWHAG, implicating it as a potential POCD biomarker.
Confidence score:

0.4032
Other information
Title:

Abnormal expression of circRNA_089763 in the plasma exosomes of patients with post‑operative cognitive dysfunction after coronary artery bypass grafting.

Journal: Molecular medicine reports
Published: 2019
PubMed ID: 31524256
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: -