| Expression pattern: |
DN |
| Associated gene: |
KLF5 |
| Associated microRNA: |
miR-141 |
| Biological function: |
circCRKL acts as a tumor suppressor in PCa; overexpression represses cell cycle progression, migration, invasion, tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
circCRKL sponges miR-141 to positively regulate KLF5 expression, thereby suppressing PCa progression. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circCRKL might be an underlying therapeutic target for PCa treatment. |
| Description: |
circCRKL is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. Mechanistically, circCRKL sponges miR-141 to upregulate KLF5, thereby inhibiting cell cycle progression, migration, invasion, and in vivo tumor growth while promoting apoptosis. |
| Confidence score: |
0.7981 |