| Expression pattern: |
UP |
| Associated gene: |
E2F1 |
| Associated microRNA: |
miR-610 |
| Biological function: |
promotes colorectal cancer cell proliferation |
| Molecular mechanism: |
Acts as a ceRNA to sponge miR-610, thereby increasing E2F1 expression and promoting proliferation. |
| Biological pathway or process: |
proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circMAT2B expression was significantly higher in CRC tissues than adjacent tissues; proposed as a biomarker/therapeutic target for CRC. |
| Description: |
circMAT2B is upregulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation. Mechanistically, circMAT2B sponges miR-610, relieving repression of the miR-610 target E2F1 and thereby increasing E2F1 expression. |
| Confidence score: |
0.7032 |