circRNA basic information
circBase ID: hsa_circ_0005797
Name: hsa_circ_ATP2C1
Synonym: Circular RNA ATP2C1
Host Gene: ATP2C1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0007254
MONDO name: breast cancer
Disease details: Breast cancer
Disease DO ID:
1612
Disease MeSH ID:
-
Disease NCIt ID:
C9335
Disease ICD11 ID:
1047754165
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

cancerous tissues; adjoining normal tissues; paracancerous tissues

Cell lines:

MDA-MB-453; MDA-MB-231; BT-549; SUM-159; MCF-10A; TB-549

In vivo animal model:

cell line-derived xenograft

circRNA-disease information
Expression pattern:
UP
Associated gene: CCND1, CyclinD1
Associated microRNA: miR-432, miR-335, miR-432-5p
Biological function: circATP2C1 promotes BC oncogenesis, tumor growth, proliferation, invasion and metastasis, inhibits apoptosis, and is associated with poor overall survival; circATP2C1 knockdown suppresses BC cell viability, colony proliferation, invasion and in vivo tumor formation while increasing apoptosis.
Molecular mechanism: circATP2C1 acts as a ceRNA that sponges miR-432 and miR-335, relieving their inhibition of CCND1 and upregulating CCND1 expression to promote breast cancer progression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); metastasis (promotes); apoptosis (inhibits); cell cycle (promotes); EMT (promotes)

Detected method:
Q
M
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis

Clinical significance:

High circATP2C1 expression is associated with shorter overall survival and poor prognosis in BC patients; circATP2C1 may serve as a biomarker for early diagnosis and a therapeutic target for BC treatment.

Description:

circATP2C1 is up-regulated in breast cancer tissues and cell lines and its high expression is linked to poorer overall survival. Functionally, circATP2C1 promotes BC cell viability, proliferation, invasion, tumor growth and metastasis while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-432/miR-335 to increase CCND1 expression.

Confidence score:

0.8571

Other information
Title:

Circular RNA ATP2C1 (has_circ_0005797) sponges miR-432/miR-335 to promote breast cancer progression through regulating CCND1 expression.

Journal: American journal of cancer research
Published: 2023
PubMed ID: 37693160
Study type:

combined biological and clinical study

Data availability: GSE182471
Code availability: -