circRNA basic information
circBase ID: -
Name: hsa_circ_MAT2B
Synonym: circMAT2B
Host Gene: MAT2B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
5672, 9256
Disease MeSH ID:
-
Disease NCIt ID:
C4978
Disease ICD11 ID:
-
Disease OMIM ID:
114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent normal colorectal tissues

Cell lines:

NCM460; HT29; HCT116; HCT8; SW480; DLD1; Caco2

In vivo animal model:

-

circRNA-disease information
Expression pattern:
UP
Associated gene: E2F1
Associated microRNA: miR-610
Biological function: promotes colorectal cancer cell proliferation
Molecular mechanism: Acts as a ceRNA to sponge miR-610, thereby increasing E2F1 expression and promoting proliferation.
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Flow Cytometry(Non-apoptosis/cycle); Western Blot; Bioinformatics Analysis

Clinical significance:

circMAT2B expression was significantly higher in CRC tissues than adjacent tissues; proposed as a biomarker/therapeutic target for CRC.

Description:

circMAT2B is upregulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation. Mechanistically, circMAT2B sponges miR-610, relieving repression of the miR-610 target E2F1 and thereby increasing E2F1 expression.

Confidence score:

0.7032

Other information
Title:

Circular RNA MAT2B Induces Colorectal Cancer Proliferation via Sponging miR-610, Resulting in an Increased E2F1 Expression.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32848465
Study type:

combined biological and clinical study

Data availability: -
Code availability: -