| Expression pattern: |
UP |
| Associated gene: |
Bmi-1 |
| Associated microRNA: |
miR-203 |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration and invasion; inhibits apoptosis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-203 to relieve repression of Bmi-1, increasing Bmi-1 expression and promoting malignant phenotypes. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; circRIP; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
High circRNA-0008717 expression correlates with poor OS and PFS and shows diagnostic value (AUC 0.782). |
| Description: |
circRNA-0008717 (circ-ABCB10) is up-regulated in osteosarcoma tissues/serum and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-203, thereby increasing Bmi-1 expression. High circRNA-0008717 expression is associated with poor patient survival and shows diagnostic potential by ROC analysis. |
| Confidence score: |
0.8229 |