circRNA basic information
circBase ID: mmu_circ_0001468
Name: mmu_circ_HIPK2
Synonym: circHIPK2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3431
DO name: cerebritis
Disease details: lipopolysaccharide-induced astrocytic inflammation
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIGMAR1
Associated microRNA: -
Biological function: Knockdown circHIPK2 in primary astrocytes suppressed the SIGMAR1 expression and inflammation
Molecular mechanism: circHIPK2/SIGMAR1 axis
Survival: -
Supported No.:
 1
Description:

These results implied that autophagy inducer rapamycin could suppress astrocytic inflammation by inactivating circHIPK2-SIGMAR1 axis.
Other information
Title:

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.

Journal: Int Immunopharmacol
Published: 2023/2/25
PubMed ID: 36827915