| Expression pattern: |
UP |
| Associated gene: |
SLC7A11, GPX4 |
| Associated microRNA: |
miR-520d-5p |
| Biological function: |
attenuates ferroptosis, promotes proliferation, inhibits apoptosis, and promotes tumor growth/progression in OSCC |
| Molecular mechanism: |
ceRNA mechanism: circFNDC3B targets (sponges) miR-520d-5p to increase SLC7A11, thereby repressing ferroptosis and promoting OSCC progression |
| Biological pathway or process: |
ferroptosis (inhibits); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circFNDC3B expression in clinical OSCC tissues was negatively correlated with prognosis |
| Description: |
circFNDC3B is up-regulated in OSCC tissues and promotes malignant progression. Functionally, it suppresses ferroptosis and apoptosis while enhancing proliferation and tumor growth. Mechanistically, circFNDC3B acts as a ceRNA for miR-520d-5p to increase SLC7A11 (and downstream GPX4), thereby reducing ferroptosis-related ROS/iron accumulation. |
| Confidence score: |
0.7126 |