circRNA basic information
circBase ID: hsa_circ_0000227
Name: hsa_circ_ZEB1
Synonym: -
Host Gene: ZEB1
Genomic location(hg19): chr10:31644072-31676195:+
Genomic location(hg38): chr10:31355143-31387266:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ARHGAP11A, DRP2, HNRNPA3, IGFBP5, IP6K2, KLF10, KPNA4, NRP2, PAIP1, RCN1, SEMA5A
Associated microRNA: miR-647, miR-1303, miR-767-3p
Biological function: Acts as a predicted ceRNA (miRNA sponge) in glioma regulatory network.
Molecular mechanism: ceRNA mechanism via predicted circRNA-miRNA interactions
Biological pathway or process:

ceRNA regulation (other); cell cycle (other); p53 signaling (other); Hippo/YAP (other); MAPK (other); Wnt/beta-catenin (other); TGF-beta/SMAD (other); stemness (other); immune regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000227 is up-regulated in glioma microarray datasets and is part of the predicted ceRNA network. It is predicted to bind miR-647, miR-1303, and miR-767-3p to indirectly regulate downstream mRNAs; this is based on database predictions without wet-lab validation.
Confidence score:

0.1768
Other information
Title:

Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.

Journal: PeerJ
Published: 2021
PubMed ID: 34434651
Study type:

bioinformatics study
Data availability: Supplementary File (codes); GEO; TCGA-GBMLGG; CGGA
Code availability: Supplementary File