| Expression pattern: |
DN |
| Associated gene: |
XPC |
| Associated microRNA: |
miR-346-5p |
| Biological function: |
circ_0069244 represses NSCLC cell proliferation, migration and lung metastasis, acting as a tumor suppressor in NSCLC. |
| Molecular mechanism: |
circ_0069244 functions as a competing endogenous RNA that sponges miR-346-5p and thereby up-regulates XPC expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; BrdU; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_0069244 under-expression is linked to shorter overall survival and poor tumor histological grade; circ_0069244 serves as a promising prognostic biomarker and therapeutic target for NSCLC patients. |
| Description: |
This study identifies circ_0069244 as a down-regulated tumor-suppressive circRNA in NSCLC. It inhibits NSCLC cell proliferation, migration and in vivo lung metastasis by sponging miR-346-5p and increasing XPC expression. Clinically, reduced circ_0069244 expression is associated with shorter overall survival and poor differentiation, supporting its potential as a prognostic biomarker and therapeutic target. |
| Confidence score: |
0.8427 |