| Expression pattern: |
UP |
| Associated gene: |
CREBBP |
| Associated microRNA: |
- |
| Biological function: |
May serve as a biomarker for NPC and may play a role in NPC development; expression distinguishes NPC tissues from paired healthy tissues and NPC cell lines from a normal epithelial cell line. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA ceRNA network; hsa_circ_0007637 originates from aberrant mRNA splicing of CREBBP. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; RNase R Treatment; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May be a biomarker for NPC; expression distinguished NPC tissues from paired healthy tissues and NPC cell lines from a normal epithelial cell line. |
| Description: |
hsa_circ_0007637 was identified by RNA-Seq and validated by qRT-PCR as up-regulated in NPC tissues and in HK1 and CNE2 NPC cell lines. The study suggests that hsa_circ_0007637, derived from the CREBBP gene, may serve as a biomarker for NPC and may participate in NPC development through predicted circRNA-miRNA-mRNA ceRNA-related mechanisms. |
| Confidence score: |
0.5135 |