| Expression pattern: |
UP |
| Associated gene: |
CDK1, Ago2 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
Promotes HCC cell proliferation, migration/metastasis, tumor growth and lung metastasis. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge binding miR-330-3p to relieve repression of CDK1. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); metastasis (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
B
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Northern Blot; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNase R Treatment; divergent primers PCR; Sanger Sequencing; Transfection; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Western Blot; CCK8; Colony Formation Assay; EdU Staining; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circSLC7A11 expression correlates with tumor size, microvascular invasion, TNM stage, and worse prognosis/overall survival in HCC patients. |
| Description: |
circSLC7A11 (hsa_circ_0070975) is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC proliferation and metastasis by sponging miR-330-3p and thereby increasing CDK1 expression, and high circSLC7A11 levels indicate worse patient prognosis. |
| Confidence score: |
0.8933 |