| Expression pattern: |
UP |
| Associated gene: |
MMP11 |
| Associated microRNA: |
miR-129-5p |
| Biological function: |
promotes cisplatin chemoresistance; promotes proliferation; promotes colony formation; inhibits apoptosis; promotes migration; promotes invasion; promotes cell adhesion; promotes tumor growth in vivo |
| Molecular mechanism: |
circ_0000260 functions as a ceRNA (miRNA sponge) for miR-129-5p to upregulate MMP11, thereby enhancing cisplatin resistance and malignant phenotypes. |
| Biological pathway or process: |
ceRNA regulation (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
High circ_0000260 expression in serum-derived exosomes and tumor tissues is associated with CDDP resistance in GAC patients. |
| Description: |
circ_0000260 (circSMC3, from SMC3) is up-regulated in GAC tumor tissues and serum-derived exosomes, especially in cisplatin-resistant cases. Functionally, it promotes cisplatin chemoresistance and malignant behaviors by acting as a ceRNA for miR-129-5p to increase MMP11 expression, and its knockdown sensitizes cells/tumors to cisplatin. |
| Confidence score: |
0.6545 |