| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-29a |
| Biological function: |
Promotes proliferation, colony formation, invasion, migration and wound healing; inhibits apoptosis in prostate cancer cells. |
| Molecular mechanism: |
Targets/negatively regulates miR-29a (miRNA sponge/ceRNA-like regulation) to promote prostate cancer progression-related phenotypes. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; TUNEL; Transwell Assay; Wound Healing Assay; Bioinformatics Analysis |
| Clinical significance: |
Provided evidence for circRNA-MYLK as a tool to use to diagnose and treat PCa. |
| Description: |
circRNA-MYLK (hsa_circ_0141940) is up-regulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation/colony formation, invasion, migration and wound healing, while inhibiting apoptosis, at least partly by targeting and downregulating miR-29a. |
| Confidence score: |
0.5751 |