| Expression pattern: |
UP |
| Associated gene: |
AURKA |
| Associated microRNA: |
miR-149-5p |
| Biological function: |
Promotes cervical cancer cell proliferation and invasion; inhibition of hsa_circ_0075341 reduces proliferation and invasion in vitro. |
| Molecular mechanism: |
hsa_circ_0075341 functions as a miR-149-5p sponge and upregulates AURKA through the hsa_circ_0075341/miR-149-5p/AURKA ceRNA axis. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
High hsa_circ_0075341 expression is associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis in cervical cancer patients; it may provide a novel therapeutic target for cervical cancer treatment. |
| Description: |
hsa_circ_0075341 is upregulated in cervical cancer tissues and is associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis. Functionally, it promotes cervical cancer cell proliferation and invasion. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-149-5p and upregulates AURKA through the hsa_circ_0075341/miR-149-5p/AURKA axis. |
| Confidence score: |
0.7357 |