| Expression pattern: |
UP |
| Associated gene: |
TGIF2, RNF13 |
| Associated microRNA: |
miR-424-5p |
| Biological function: |
promotes proliferation, colony formation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo; promotes HBV expression and replication |
| Molecular mechanism: |
ceRNA sponging miR-424-5p to regulate TGIF2 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); ceRNA regulation (promotes); viral replication (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; ELISA; In Vivo Animal Model; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-RNF13 is up-regulated in HBV-associated HCC tissues and HBV-expressing HCC cells, mainly localized in the cytoplasm. It promotes malignant phenotypes and HBV replication by sponging miR-424-5p and positively regulating TGIF2 in a ceRNA axis. |
| Confidence score: |
0.7421 |