circRNA basic information
circBase ID: hsa_circ_0017639
Name: hsa_circ_SFMBT2
Synonym: circ_0017639
Host Gene: SFMBT2
Genomic location(hg19): chr10:7290509-7327916:-
Genomic location(hg38): chr10:7248547-7285954:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; paracancerous tissue samples
Cell lines:

A549; H1299; H1755; H2170; 16HBE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PI3K, AKT, PIK3R3, AKT3
Associated microRNA: miR-224-5p
Biological function: promotes proliferation, migration, and invasion; promotes xenograft tumor growth
Molecular mechanism: activates the PI3K/AKT signaling cascade (increased p-PI3K and p-AKT), and AKT activator SC97 reverses effects of circ_0017639 knockdown
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Actinomycin D / DRB Stability Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Clinical Sample Validation
Clinical significance:

high circ_0017639 expression is associated with shorter overall survival in NSCLC patients
Description:

circ_0017639 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it enhances PI3K/AKT signaling activity (increased PI3K/AKT phosphorylation), and AKT activation (SC97) rescues the inhibitory effects of circ_0017639 knockdown.
Confidence score:

0.7451
Other information
Title:

Circ_0017639 facilitates proliferative, migratory, and invasive potential of non-small cell lung cancer (NSCLC) cells via PI3K/AKT signaling pathway.

Journal: Bioengineered
Published: 2022
PubMed ID: 35000535
Study type:

combined biological and clinical study
Data availability: The authors confirm that the data supporting the findings of this study are available within the article.
Code availability: -