| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-532-3p |
| Biological function: |
Promotes CRC cell proliferation, migration and invasion; inhibits apoptosis; reduces sensitivity to 5-FU (promotes chemoresistance). |
| Molecular mechanism: |
circNRIP1 functions as a ceRNA by sponging miR-532-3p, thereby suppressing miR-532-3p and modulating 5-FU chemosensitivity in CRC cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Bioinformatics Analysis; Survival Analysis; ROC Analysis |
| Clinical significance: |
High circNRIP1 expression is associated with CRC progression, metastasis/TNM stage, poor overall survival, and shows diagnostic value (ROC) for lymph node metastasis, distant metastasis and TNM stage. |
| Description: |
circNRIP1 is up-regulated in colorectal cancer and behaves as an oncogenic circRNA, promoting proliferation/migration/invasion and inhibiting apoptosis. It decreases CRC cell sensitivity to 5-FU by sponging miR-532-3p; knockdown of circNRIP1 increases miR-532-3p and sensitizes cells to 5-FU. High circNRIP1 is associated with advanced disease features and poor overall survival, with potential diagnostic utility (ROC). |
| Confidence score: |
0.7365 |