circRNA basic information
circBase ID: -
Name: hsa_circ_RBM22
Synonym: hsa_circ_406697
Host Gene: RBM22
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer lesions; adjacent normal-appearing tissues; breast cancer tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-6873-3p, hsa-miR-6833-3p, hsa-miR-6845-3p, hsa-miR-6742-5p, hsa-miR-100-3p
Biological function: Proposed diagnostic biomarker (in combination) and potentially involved in carcinogenesis.
Molecular mechanism: Predicted miRNA sequestration via MREs (miRNA sponge/ceRNA-like mechanism).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic performance assessed by ROC; in combination with hsa_circ_006054 and hsa_circ_100219 AUC = 0.82 (95% CI: 0.73-0.90).
Description:

hsa_circ_406697 is down-regulated in breast cancer tissues and, when combined with hsa_circ_006054 and hsa_circ_100219, improves diagnostic discrimination (AUC 0.82); it is predicted to interact with several miRNAs including hsa-miR-100-3p.
Confidence score:

0.5963
Other information
Title:

Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.

Journal: Oncotarget
Published: 2017
PubMed ID: 28484086
Study type:

combined biological and clinical study
Data availability: -
Code availability: -