circRNA basic information
circBase ID: hsa_circ_0004789
Name: hsa_circ_SMURF2
Synonym: -
Host Gene: SMURF2
Genomic location(hg19): chr17:62587201-62594608:-
Genomic location(hg38): chr17:64591083-64598490:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

fresh frozen LUAD tissues; adjacent non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: C1orf115
Associated microRNA: hsa-miR-877-5p
Biological function: -
Molecular mechanism: ceRNA mechanism
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0004789 is down-regulated in LUAD tissues versus adjacent non-tumor tissues and is included in the final ceRNA hub network. It is proposed to act via a ceRNA axis hsa_circ_0004789/hsa-miR-877-5p/C1orf115 in LUAD.
Confidence score:

0.4032
Other information
Title:

A Novel circRNA-miRNA-mRNA Hub Regulatory Network in Lung Adenocarcinoma.

Journal: Frontiers in genetics
Published: 2021
PubMed ID: 34306017
Study type:

combined biological and clinical study
Data availability: GSE101586; GSE101684; GSE112214; GSE135918; GSE32863; GSE26939; TCGA
Code availability: -