| Expression pattern: |
DN |
| Associated gene: |
PRICKLE2 |
| Associated microRNA: |
miR-665 |
| Biological function: |
Suppresses LUAD cell proliferation, migration, and invasion |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-665, thereby regulating PRICKLE2 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA-seq; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Clinical Sample Validation |
| Clinical significance: |
suggesting that circ-000881 may be an underlying therapeutic target for LUAD |
| Description: |
Circ-000881 is down-regulated in LUAD tissues and cell lines and functions as a tumor suppressor in vitro by inhibiting proliferation, migration and invasion. Mechanistically, it acts as a ceRNA sponge for miR-665 to relieve repression of PRICKLE2, forming a circ-000881/miR-665/PRICKLE2 axis. |
| Confidence score: |
0.6815 |