circRNA basic information
circBase ID: -
Name: hsa_circ_FAM120B
Synonym: circFAM120B
Host Gene: FAM120B
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

LoVo; HCT15; SW620; HCT116; HCT8; CACO2; NCM460
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: TGFBR2, HK2, LDHA, Ago2
Associated microRNA: miR-645
Biological function: inhibits colorectal cancer cell proliferation, migration/invasion, glycolysis metabolism, and tumor growth
Molecular mechanism: circFAM120B sponges miR-645 to activate TGFBR2 expression (ceRNA network)
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); glycolysis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry)
Clinical significance:

-
Description:

In colorectal cancer, circFAM120B is down-regulated and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion, glycolysis, and xenograft tumor growth by sponging miR-645 to relieve repression of TGFBR2 (circFAM120B/miR-645/TGFBR2 axis).
Confidence score:

0.8197
Other information
Title:

CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645.

Journal: Frontiers in cell and developmental biology
Published: 2021
PubMed ID: 34381772
Study type:

combined biological and clinical study
Data availability: GSE1260943; https://www.frontiersin.org/articles/10.3389/fcell.2021.682543/full#supplementary-material
Code availability: -