| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-1324 |
| Biological function: |
promoted gastric cancer cell proliferation, migration and invasion and inhibited apoptosis; weakened propofol-induced tumor suppression in vivo |
| Molecular mechanism: |
circPDSS1 sponges miR-1324 to regulate SOX4 expression in propofol-treated gastric cancer cells |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In gastric cancer, circPDSS1 is upregulated in tumor tissues and promotes malignant phenotypes. Propofol suppresses GC progression partly by downregulating circPDSS1, which otherwise sponges miR-1324 to increase SOX4 expression and enhance proliferation/migration/invasion while reducing apoptosis. |
| Confidence score: |
0.8006 |