| Expression pattern: |
UP |
| Associated gene: |
FOXM1 messenger RNA (mRNA), FOXM1 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
Circ-PTK2 promotes proliferation and inhibits apoptosis of AML cells; circ-PTK2 silencing suppresses proliferation and induces apoptosis. |
| Molecular mechanism: |
Circ-PTK2 acts as a miR-330-5p sponge to up-regulate FOXM1 expression in AML cells. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-PTK2 expression is associated with shorter survival time and low survival rate in AML patients; it might be a biomarker for poor prognosis. |
| Description: |
Circ-PTK2 is up-regulated in AML bone marrow samples and AML cell lines, and high expression is associated with shorter survival. Functionally, circ-PTK2 promotes AML cell proliferation and suppresses apoptosis. Mechanistically, circ-PTK2 sponges miR-330-5p to increase FOXM1 expression, forming a circ-PTK2/miR-330-5p/FOXM1 regulatory axis. |
| Confidence score: |
0.7113 |