circRNA basic information
circBase ID: hsa_circ_0007456
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:11984672-12016677:+
Genomic location(hg38): chr17:12081355-12113360:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC; paracancerous liver tissues; matched non-tumor liver tissues; adjacent non-tumor liver tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: hsa-mir-182, hsa-mir-346
Biological function: Might be involved in carcinogenesis and development of HCC via a predicted circRNA-miRNA-mRNA regulatory network.
Molecular mechanism: Predicted miRNA sponge (ceRNA), including potential sponging of hsa-mir-346 and binding sites for hsa-mir-182.
Biological pathway or process:

cell cycle (other); p53 signaling (other); proliferation (other); ceRNA regulation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0007456 is a top-ranked differentially expressed circRNA in HCC from integrated microarray analysis. It is predicted to function as a ceRNA by binding hsa-mir-182 and potentially sponging hsa-mir-346, contributing to circRNA-miRNA-mRNA modules enriched in cell cycle and p53 signaling-related genes.
Confidence score:

0.1768
Other information
Title:

Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Hepatocellular Carcinoma by Integrated Microarray Analysis.

Journal: Medical science monitor basic research
Published: 2018
PubMed ID: 29706616
Study type:

bioinformatics study
Data availability: GSE94508; GSE97332; GSE22058
Code availability: -