circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissue; matched normal counterpart
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: HPSE
Associated microRNA: miR-558
Biological function: suppresses invasion; metastasis; angiogenesis of bladder cancer cells
Molecular mechanism: miRNA sponging of miR-558 leading to repression of HPSE
Biological pathway or process:

invasion (inhibits); metastasis (inhibits); angiogenesis (inhibits); ceRNA regulation (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

In bladder cancer RNA-seq samples, circHIPK3 is reported as down-regulated. The paper’s case study detects the previously described circHIPK3-miR-558-HPSE axis, consistent with a tumor-suppressive role of circHIPK3 via miR-558 sponging and HPSE repression.
Confidence score:

0.1768
Other information
Title:

CircIMPACT: An R Package to Explore Circular RNA Impact on Gene Expression and Pathways.

Journal: Genes
Published: 2021
PubMed ID: 34356060
Study type:

bioinformatics study
Data availability: GSE97239
Code availability: GitHub