| Expression pattern: |
UP |
| Associated gene: |
VEGF |
| Associated microRNA: |
miR-29a |
| Biological function: |
Promotes HUVEC proliferation, migration/invasion and tube formation/angiogenesis; promotes GC cell migration; promotes tumor growth and angiogenesis in vivo. |
| Molecular mechanism: |
Exosome-delivered circ29 acts as a sponge of miR-29a and regulates VEGF expression/pathway in endothelial cells. |
| Biological pathway or process: |
VEGF/VEGFR (promotes); angiogenesis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; Tube Formation Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Potential therapeutic target and novel clinical marker for GC. |
| Description: |
Exosomal circ29 is up-regulated in GC plasma and GC cells and is mainly carried in plasma exosomes. It promotes endothelial proliferation, migration/invasion, tube formation, angiogenesis and tumor growth by sponging miR-29a and increasing VEGF signaling/expression. The study suggests circ29 may be a therapeutic target and potential clinical marker for GC. |
| Confidence score: |
0.7369 |