circRNA basic information
circBase ID: -
Name: hsa_circ_SMARCA5
Synonym: -
Host Gene: SMARCA5
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tumor tissues; adjacent normal tissues
Cell lines:

16HBE; A549; H1299; H1975; H358
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: HOXA9
Associated microRNA: miR-19b-3p
Biological function: inhibits proliferation, migration, and invasion; suppresses tumor growth in vivo
Molecular mechanism: acts as a miRNA sponge for miR-19b-3p to regulate HOXA9
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

circSMARCA5 is down-regulated in NSCLC tissues and cell lines and functions as a tumor suppressor. Its overexpression inhibits NSCLC cell proliferation, migration, and invasion and suppresses xenograft tumor growth, mainly by sponging miR-19b-3p to regulate HOXA9.
Confidence score:

0.6479
Other information
Title:

Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis.

Journal: OncoTargets and therapy
Published: 2019
PubMed ID: 31564891
Study type:

combined biological and clinical study
Data availability: -
Code availability: -