| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-1208 |
| Biological function: |
Silencing circPVT1 enhanced radiosensitivity, inhibited NSCLC cell growth and invasion, promoted apoptosis, and increased gamma-H2AX expression after irradiation. |
| Molecular mechanism: |
circPVT1 acts as a competing endogenous RNA that sponges miR-1208; circPVT1 silencing up-regulates miR-1208 and blocks the PI3K/AKT/mTOR signaling pathway. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); EMT (promotes); radioresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; TUNEL; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Bioinformatics Analysis |
| Clinical significance: |
circPVT1 may become a potential target of radiosensitivity enhancement in NSCLC. |
| Description: |
circPVT1 is up-regulated in NSCLC cell lines and further induced by irradiation. Its silencing enhances radiosensitivity, inhibits proliferation and invasion, promotes apoptosis, and blocks PI3K/AKT/mTOR signaling through up-regulation of miR-1208, supporting circPVT1 as a potential radiosensitivity-related therapeutic target in NSCLC. |
| Confidence score: |
0.627 |