| Expression pattern: |
UP |
| Associated gene: |
PTK2, CD163+ M2 macrophages, CD206+ M2 macrophages, MDSCs, Kras |
| Associated microRNA: |
- |
| Biological function: |
promotes Kras-driven intratumoral heterogeneity, immunosuppression and lymph node metastasis via M2 macrophage-related mechanisms |
| Molecular mechanism: |
circHIPK3/PTK2 axis associated with MDSC differentiation and CD163+/CD206+ M2 macrophage infiltration; exosomal circHIPK3 linked to metastatic immunosuppression |
| Biological pathway or process: |
immune regulation (promotes); metastasis (promotes); migration (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; In Vivo Animal Model; Transfection; Transwell Assay |
| Clinical significance: |
exosomal serum circPTK2/circHIPK3 associated with lymph node metastasis and shows diagnostic performance in metastatic NSCLC (ROC/AUC reported) |
| Description: |
circHIPK3 is upregulated in NSCLC tissues and participates in a circHIPK3/circPTK2-associated immunosuppressive circuit linked to CD163+/CD206+ M2 macrophage infiltration and metastatic progression. Its exosomal presence in serum is associated with advanced-stage (metastatic) NSCLC and shows diagnostic value by ROC/AUC analysis. |
| Confidence score: |
0.6028 |