| Expression pattern: |
UP |
| Associated gene: |
SOX11 |
| Associated microRNA: |
miR-145-5p |
| Biological function: |
Promotes bladder cancer cell proliferation and inhibits apoptosis; knockdown causes G1/S arrest. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-145-5p to indirectly increase SOX11 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; Transfection; MTT; EdU Staining; TUNEL; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
Associated with tumor size, TNM stage and lymphatic metastasis in bladder cancer patients. |
| Description: |
circCEP128 is up-regulated in bladder cancer and mainly localizes to the cytoplasm. It promotes proliferation and inhibits apoptosis by acting as a ceRNA sponge for miR-145-5p, thereby increasing SOX11 expression; circCEP128 knockdown induces G1/S arrest and apoptosis in bladder cancer cells. |
| Confidence score: |
0.7859 |