| Expression pattern: |
UP |
| Associated gene: |
ZFX |
| Associated microRNA: |
miR-1296 |
| Biological function: |
promotes proliferation, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ_0000520 sponges miR-1296 to increase ZFX expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; Western Blot; H&E Staining |
| Clinical significance: |
High expression of circ_0000520 was associated with shorter survival time in TNBC patients |
| Description: |
circ_0000520 is up-regulated in TNBC tissues and cell lines and promotes TNBC cell proliferation, migration, invasion and xenograft growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-1296 to increase ZFX expression, and high circ_0000520 expression is associated with worse survival. |
| Confidence score: |
0.8148 |