| Expression pattern: |
UP |
| Associated gene: |
CDK1, CCNA2, CCNB1, PPP2R1A, CHEK1, KIF23, BIRC5, OIP5, RAD51, RACGAP1 |
| Associated microRNA: |
hsa-miR-590-3p, hsa-miR-15a-5p, hsa-miR-23c, hsa-miR-29a-3p, hsa-miR-424 -5p, hsa-miR-497-5p, hsa-miR-592 |
| Biological function: |
Promotes HCC progression and is associated with early recurrence; may promote tumor development by regulating cell cycle-related pathways via a ceRNA network. |
| Molecular mechanism: |
ceRNA mechanism: circ_0130911 may sponge multiple down-regulated miRNAs to regulate target mRNAs (hub genes) related to cell cycle. |
| Biological pathway or process: |
cell cycle (promotes); ceRNA regulation (other); PI3K/AKT (other); p53 signaling (other) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ_0130911 expression is an independent risk factor for death and recurrence, and indicates worse overall survival and tumor-free (disease-free) survival in HCC patients. |
| Description: |
circ_0130911 (hsa_circ_0130911), derived from UTRN, is up-regulated in HCC tissues and higher in early recurring HCC. It is associated with poor prognosis and may function as a ceRNA by sponging multiple miRNAs to regulate cell cycle-related hub genes within a predicted circRNA-miRNA-mRNA network. |
| Confidence score: |
0.6201 |