| Expression pattern: |
DN |
| Associated gene: |
SUMO2 mRNA, GLUT1, UBC9, AMPK, mTOR |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion; inhibits metastasis; inhibits glycolysis |
| Molecular mechanism: |
binds to the 3′-UTR of SUMO2 mRNA and increases SUMO2 mRNA stability; SUMO2 promotes GLUT1 SUMOylation and ubiquitination leading to GLUT1 degradation; inhibits glycolysis and regulates AMPK-mTOR signaling |
| Biological pathway or process: |
glycolysis (inhibits); AMPK (promotes); PI3K/AKT/mTOR (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ubiquitination (promotes); other pathway/process (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Cell Cycle Assay; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Co-IP; IF (Immunofluorescence); ISH (In Situ Hybridization); IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circRNF13 is down-regulated in nasopharyngeal carcinoma tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation and metastasis. Mechanistically, it binds the 3′-UTR of SUMO2 mRNA to stabilize it, increasing SUMO2, which promotes GLUT1 SUMOylation/ubiquitination and degradation, suppressing glycolysis and modulating AMPK-mTOR signaling. |
| Confidence score: |
0.8531 |