| Expression pattern: |
UP |
| Associated gene: |
FOXM1 |
| Associated microRNA: |
miR-1224-5p |
| Biological function: |
promotes cell proliferation, migration, invasion, tumor growth and glycolysis; inhibits apoptosis in colorectal cancer |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-1224-5p to regulate FOXM1 expression; also secreted in exosomes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; Transfection; In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
CRC patients with high circ-RNF121 expression had a poor overall survival compared with patients with low circ-RNF121 expression. |
| Description: |
circ-RNF121 is up-regulated in colorectal cancer and promotes malignant behaviors (proliferation, migration/invasion, tumor growth) and glycolysis while inhibiting apoptosis. Mechanistically, it functions as a miR-1224-5p sponge to upregulate FOXM1 (circ-RNF121/miR-1224-5p/FOXM1), and it can be secreted in exosomes. |
| Confidence score: |
0.7662 |