| Expression pattern: |
UP |
| Associated gene: |
JAZF1, AGO2 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
promotes lipolysis and inhibits adipogenesis |
| Molecular mechanism: |
ceRNA mechanism: circPTK2 sponges miR-182-5p to relieve repression of JAZF1 |
| Biological pathway or process: |
lipid metabolism (other); lipolysis (promotes); adipogenesis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; Oil Red O Staining; Western Blot; IHC (Immunohistochemistry); IF (Immunofluorescence); ELISA; In Vivo Animal Model; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circPTK2 could be used as a diagnostic marker for CAC (AUC 0.796; specificity 0.854; sensitivity 0.690). |
| Description: |
circPTK2 is up-regulated in subcutaneous adipose tissue from cancer-associated cachexia patients and promotes lipolysis while inhibiting adipogenesis. It acts as a ceRNA by sponging miR-182-5p, thereby relieving repression of JAZF1, and shows diagnostic value for CAC in adipose tissue. |
| Confidence score: |
0.879 |