circRNA basic information
circBase ID: hsa_circ_0012098
Name: hsa_circ_KDM4A
Synonym: circ_0012098 / Circular RNA lysine demethylase 4A
Host Gene: KDM4A
Genomic location(hg19): chr1:44159664-44171189:+
Genomic location(hg38): chr1:43693993-43705518:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum exosomes; PC tissues; adjacent normal prostate tissues; serum samples
Cell lines:

RWPE-1; PC3; 22RV1; DU145; C4-2; LNcaP; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CUL4B
Associated microRNA: miR-338-3p
Biological function: Promotes prostate cancer cell proliferation, migration, invasion and tumor growth, and inhibits apoptosis.
Molecular mechanism: Exosomal circKDM4A functions as a miR-338-3p sponge to induce CUL4B production, thereby promoting prostate cancer malignant progression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; IHC (Immunohistochemistry); Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

Exosomal circKDM4A provides a therapeutic target for prostate cancer.
Description:

Exosomal circKDM4A is up-regulated in serum exosomes, tissues and cells from prostate cancer. It promotes malignant phenotypes including proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through a circKDM4A/miR-338-3p/CUL4B regulatory axis.
Confidence score:

0.8299
Other information
Title:

Exosomal circKDM4A Induces CUL4B to Promote Prostate Cancer Cell Malignancy in a miR-338-3p-Dependent Manner.

Journal: Biochemical genetics
Published: 2023
PubMed ID: 35930171
Study type:

combined biological and clinical study
Data availability: Supplementary material available at https:// doi. org/ 10. 1007/ s10528-022-10251-2
Code availability: -