| Expression pattern: |
UP |
| Associated gene: |
LOXL2 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
promotes CC cell proliferation, migration, and invasion |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-195-5p, thereby de-repressing/up-regulating LOXL2 expression |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Higher circ_0000228 expression was associated with higher stage (stage II vs stage I) in CC tissues. |
| Description: |
circ_0000228 is up-regulated in cervical cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). It mainly localizes to the cytoplasm and acts as a ceRNA sponging miR-195-5p to increase LOXL2 expression, forming a circ_0000228/miR-195-5p/LOXL2 axis. |
| Confidence score: |
0.692 |