| Expression pattern: |
UP |
| Associated gene: |
JAK2 |
| Associated microRNA: |
miR-377-3p |
| Biological function: |
promotes cisplatin (CDDP) resistance, proliferation, migration, invasion, and tumor growth; inhibits apoptosis |
| Molecular mechanism: |
Exosomal circ_0000337 acts as a miRNA sponge (ceRNA) for miR-377-3p to regulate JAK2 expression, thereby enhancing CDDP resistance. |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Exosomal circ_0000337 is up-regulated in CDDP-resistant esophageal cancer tissues/cells and promotes cisplatin resistance and malignant phenotypes. Mechanistically, it sponges miR-377-3p to derepress JAK2, enhancing tumor growth and CDDP resistance in vitro and in a xenograft model. |
| Confidence score: |
0.705 |