| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-497 |
| Biological function: |
promotes HCC cell proliferation and migration |
| Molecular mechanism: |
suppresses the maturation of miR-497 from precursor to mature miRNA |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
High expression levels of circRNA SCARB1 were significantly correlated with higher level of AFP, larger tumor size, vascular invasion and TNM stage III. |
| Description: |
circRNA SCARB1 is up-regulated in hepatocellular carcinoma and promotes HCC cell proliferation and migration. Mechanistically, it suppresses the maturation of miR-497 (reducing mature miR-497 without affecting its precursor), and miR-497 overexpression partially rescues SCARB1-driven phenotypes. |
| Confidence score: |
0.5546 |