| Expression pattern: |
DN |
| Associated gene: |
SOCS6 |
| Associated microRNA: |
miR-1278 |
| Biological function: |
inhibits proliferation, colony formation, invasion, and EMT; induces apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
acts as a miR-1278 sponge and promotes SOCS6 expression |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); EMT (inhibits); apoptosis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation; Cohort Study; Survival Analysis |
| Clinical significance: |
reduced expression indicated poor prognosis |
| Description: |
circ_0015278 is down-regulated in NSCLC and acts as a tumor suppressor. It sponges miR-1278 to relieve repression of SOCS6, thereby inhibiting proliferation, invasion and EMT and promoting apoptosis, and it suppresses xenograft tumor growth. Low circ_0015278 expression is associated with worse patient survival. |
| Confidence score: |
0.8824 |