circRNA basic information
circBase ID: hsa_circ_0008274
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr13:96485180-96489456:-
Genomic location(hg38): chr13:95832926-95837202:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor samples; adjacent normal tissue samples
Cell lines:

Huh-7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ESRP2
Associated microRNA: -
Biological function: -
Molecular mechanism: ESRP2 may inhibit circRNA biogenesis/expression (splicing regulation).
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection
Clinical significance:

-
Description:

hsa_circ_0008274 is up-regulated in HCC and increases upon ESRP2 knockdown in Huh-7 cells, suggesting ESRP2 normally represses its biogenesis/expression via splicing regulation.
Confidence score:

0.3213
Other information
Title:

Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2021
PubMed ID: 34299096
Study type:

bioinformatics study
Data availability: GSE94508; GSE97332; TCGA-LIHC
Code availability: -