circRNA basic information
circBase ID: hsa_circ_0008016
Name: hsa_circ_FGFR1
Synonym: -
Host Gene: FGFR1
Genomic location(hg19): chr8:38287199-38287466:-
Genomic location(hg38): chr8:38429681-38429948:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor samples; adjacent normal tissue samples
Cell lines:

Huh-7; HepG2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ESRP2, PCBP2
Associated microRNA: -
Biological function: -
Molecular mechanism: ESRP2 may inhibit circRNA biogenesis/expression (splicing regulation).
Biological pathway or process:

other pathway/process (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; CLIP
Clinical significance:

-
Description:

hsa_circ_0008016 (from FGFR1) is up-regulated in HCC and increases upon ESRP2 knockdown in Huh-7 cells, consistent with ESRP2 acting as a negative RBP regulator of its biogenesis/expression. ENCODE eCLIP data support binding of PCBP2 near its upstream splice region.
Confidence score:

0.4468
Other information
Title:

Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.

Journal: International journal of molecular sciences
Published: 2021
PubMed ID: 34299096
Study type:

bioinformatics study
Data availability: GSE94508; GSE97332; ENCSR339FUY; TCGA-LIHC
Code availability: -