| Expression pattern: |
DN |
| Associated gene: |
ANKRD46 |
| Associated microRNA: |
miR-25-3p |
| Biological function: |
Circ_PRDM5 suppresses breast cancer cell viability, proliferation, migration, invasion and tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_PRDM5 functions as a miR-25-3p sponge to upregulate ANKRD46, thereby inhibiting malignant progression of breast cancer. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); metastasis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; EdU Staining; Colony Formation Assay; Western Blot; Transwell Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
Circ_PRDM5 might be used as a therapeutic biomarker to inhibit the development and metastasis of BC. |
| Description: |
Circ_PRDM5 is downregulated in breast cancer tissues and cells. Functionally, its overexpression suppresses BC cell viability, proliferation, migration, invasion and xenograft tumor growth, while promoting apoptosis. Mechanistically, circ_PRDM5 acts as a sponge for miR-25-3p to increase ANKRD46 expression, forming a circ_PRDM5/miR-25-3p/ANKRD46 regulatory axis. |
| Confidence score: |
0.786 |