| Expression pattern: |
UP |
| Associated gene: |
ANLN |
| Associated microRNA: |
miR-153-3p |
| Biological function: |
promotes lapatinib resistance, proliferation/viability, colony formation, migration and invasion; inhibits apoptosis in lapatinib-resistant breast cancer cells; promotes tumor growth and reduces drug sensitivity in vivo |
| Molecular mechanism: |
Exosomal circ-MMP11 acts as a ceRNA (miRNA sponge) for miR-153-3p, thereby upregulating ANLN |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; ROC Analysis; Survival Analysis; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
ROC curve analysis indicated AUC=0.9444 for circ-MMP11; high circ-MMP11 level associated with lower overall survival rate in LR breast cancer patients |
| Description: |
Circ-MMP11 is up-regulated in lapatinib-resistant breast cancer tissues/cells and can be transported via exosomes. It promotes lapatinib resistance and malignant phenotypes by sponging miR-153-3p and derepressing ANLN; circ-MMP11 knockdown sensitizes cells and xenografts to lapatinib. |
| Confidence score: |
0.8353 |