| Expression pattern: |
UP |
| Associated gene: |
GLUT3 |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
Promotes proliferation, migration, invasion, and glycolysis (glucose consumption and lactate production) in NSCLC cells. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-195-5p, relieving repression of GLUT3. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot |
| Clinical significance: |
High circMYLK expression was associated with larger tumor size, advanced TNM stage, and poorer overall survival in NSCLC patients. |
| Description: |
circMYLK is up-regulated in NSCLC and promotes malignant phenotypes (proliferation, migration, invasion) and glycolysis. Mechanistically, it sponges miR-195-5p to increase GLUT3 expression, and high circMYLK correlates with poor overall survival. |
| Confidence score: |
0.7113 |