circRNA basic information
circBase ID: hsa_circ_0001479
Name: hsa_circ_ZNF131
Synonym: -
Host Gene: ZNF131
Genomic location(hg19): chr5:43122140-43162033:+
Genomic location(hg38): chr5:43122038-43161931:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC primary tumors; adjacent non-tumor tissue; tumor tissue
Cell lines:

BGC-823; HGC-27; AGS; GES-1; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: DEK, beta-catenin, c-Myc, ZNF131, CD8 + T cells, PD-1, PD-L1 (CD274), PD-L2 (PDCD1LG2), CTLA4, IDO1, CD47, TIM3 (HAVCR2), PVR
Associated microRNA: miR-133a-5p
Biological function: Promotes gastric cancer cell proliferation, migration, invasion, tumorigenesis, metastasis, and immune escape by reducing CD8 + T cell infiltration.
Molecular mechanism: hsa_circ_0001479 acts as a ceRNA sponge for miR-133a-5p to upregulate DEK, activating Wnt/beta-catenin signaling and c-Myc accumulation; c-Myc transcriptionally activates ZNF131 to stimulate hsa_circ_0001479 generation, forming a feedback loop. hsa_circ_0001479 also alters the immune microenvironment through DEK and is associated with immune checkpoints.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes); immune regulation (promotes); other pathway/process (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Western Blot; IF (Immunofluorescence); ChIP / ChIP-seq; Bioinformatics Analysis
Clinical significance:

High hsa_circ_0001479 expression is associated with tumor infiltration depth, lymph node metastasis, distant metastasis, TNM stage, and may serve as a biomarker for predicting immunotherapy efficacy in GC patients.
Description:

hsa_circ_0001479 is upregulated in gastric cancer and functions as an oncogenic circRNA that promotes GC cell proliferation, migration, invasion, and in vivo tumor growth. Mechanistically, it sponges miR-133a-5p to upregulate DEK and activate Wnt/beta-catenin/c-Myc signaling, while c-Myc further enhances hsa_circ_0001479 generation through ZNF131 promoter activation. The circRNA also contributes to immune escape by reducing CD8 + T cell infiltration and correlating with immune checkpoint molecules, suggesting potential immunotherapy biomarker value.
Confidence score:

0.8686
Other information
Title:

Hsa_circ_0001479 accelerates tumorigenesis of gastric cancer and mediates immune escape.

Journal: International immunopharmacology
Published: 2023
PubMed ID: 37683398
Study type:

combined biological and clinical study
Data availability: GSE93541; GSE89143; https://doi.org/10.1016/j.intimp.2023.110887; Data will be made available on request
Code availability: -